Learn how to say Downers correctly in English with this tutorial pronunciation video.
Oxford dictionary definition of the word downer:
1 (usually downers) a depressant or tranquillizing drug, especially a barbiturate:
during that week I was heavily doped on downers
2a dispiriting or depressing experience or factor:
the thought of the danger his son was in put something of a downer on the situation
3a cow or other animal that has fallen down and cannot get to its feet unaided.