Learn how to say Depopulate correctly in English with this tutorial pronunciation video.
Oxford dictionary definition of the word depopulate:
substantially reduce the population of (an area):
the disease could depopulate a town the size of Bournemouth
mid 16th century (in the sense ‘ravage, lay waste’): from Latin depopulat- ‘ravaged’, from the verb depopulari, from de- ‘completely’ + populari ‘lay waste’ (from populus ‘people’)